Response Assessment in Neuro-Oncology (RANO) Working Group

USA

The Response Assessment in Neuro-Oncology (RANO) Working Group is an international, multidisciplinary network of neuro-oncologists, radiologists, neurosurgeons, and researchers committed to improving the evaluation of treatment responses in brain and central nervous system (CNS) tumors. Formed in response to the limitations of traditional response criteria, the RANO Working Group develops and standardizes updated guidelines that reflect the complexities of modern therapies and imaging technologies. These guidelines are widely adopted in clinical trials and clinical practice, ensuring consistent and meaningful assessment of tumor progression and treatment efficacy. Through global collaboration and consensus-building, RANO plays a crucial role in advancing clinical trial design, regulatory approval processes, and ultimately, patient care in neuro-oncology.